Pro-lipo Neo, DIY Liposomes
Attention: The manufacture will no longer allow us to resell this material in small quantities. You must contact the manufacturer directly to purchase. This material will not be restocked.
Easily create your own custom Liposomes with this this ready-to-use liposomal pre-mix. Simply add your active and you have your very own liposomes to enhance any product formulations. This innovative product makes it easy to customize and create to help your products to stand out and enhances the efficacy of your formulations by improving penetration of your active ingredients.
Pro-Lipo™ Neo is a ready-to-use mixture of selected phospholipids already organized in lamellar bilayers by their solubilization in an appropriate medium. This pro-liposome structure requires only the addition of a water phase to spontaneously form, at room temperature, an alcohol free suspension of multilamellar liposomes (mainly bilamellar) of a mean size of 250 nm.
Able to entrap hydrosoluble and/or liposoluble active ingredients, Pro-Lipo™ Neo technology allows the selection of the type and concentration of the ingredients to entrap, offering the possibility to customize liposomes.
Product Benefits
Formulation Advice
Please be advised that this ingredient is for a more advances skill level and requires an overhead mixer for the proper formation of the liposomes.
Additionally, one must be able to calculate the appropriate concentration of their active ingredients by using the mathematical equation as provided by the supplier.
All powders must be first completely dissolved or suspended in a liquid medium prior to adding to the phospholipids. Although you can use lipophilic materials, we have always preferred to formulate with hydrophilic ingredients for our liposomes. When formulating with only hydrophilic materials, the equation is much more simple.
Optimal pH: 5-8
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A premix (liposome suspension) should be prepared in water and should be added to the formula at a temperature below 40°C.
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The calculation:
the % of active (includes the powder and water together) = ACTIVE
ACTIVE x 0.11 = minimum amount of phospholipids needed
ACTIVE x 0.43 = maximum amount of phospholipids needed
- To determine your ideal concentration may take some trial and error. Personally, we tend to formulate in the higher range of phospholipids in order to ensure stable liposomes.
To process, you will pour the water phase containing your active materials that you wish to encapsulate into the vessel contain the Pro-Lipo Neo. Place the vessel containing the two phases under an overhead mixer, without pre-mixing, slowly increase the speed to 800-1000 rpm. To achieve optimal efficacy, you must process the mixture at a minimum of 800 rpm for a minimum of 30 minutes.
If your liposomes are stable, you will not see any layers form in the beaker and the mixture will look fully homogeneous.
Specifications
Documents
Documents
Documents
INCI: Propanediol, Lecithin
Use: 0.1 – 3.0%
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